2AXI

HDM2 in complex with a beta-hairpin

Summary for 2AXI

• Entry DOI: 10.2210/pdb2axi/pdb
• Related PRD ID: PRD_000326
• Descriptor: Ubiquitin-protein ligase E3 Mdm2, cyclic 8-mer peptide, SULFATE ION, ... (5 entities in total)
• Functional Keywords: p53, drug design, protein-protein interactions, ligase, ligase-ligase inhibitor complex, ligase/ligase inhibitor
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 2
• Total formula weight: 15165.55

Authors

Mittl, P.R.E.,Fasan, R.,Robinson, J.,Gruetter, M.G. (deposition date: 2005-09-05, release date: 2006-03-21, Last modification date: 2023-08-23)

• Primary citation: Fasan, R.,Dias, R.L.,Moehle, K.,Zerbe, O.,Obrecht, D.,Mittl, P.R.,Robinson, J.A.; Structure-Activity Studies in a Family of beta-Hairpin Protein Epitope Mimetic Inhibitors of the p53-HDM2 Protein-Protein Interaction.; Chembiochem, 7:515-526, 2006; PubMed: 16511824; DOI: 10.1002/cbic.200500452

Experimental method

X-RAY DIFFRACTION (1.4 Å)