2AX0
Hepatitis C Virus NS5b RNA Polymerase in complex with a covalent inhibitor (5x)
Summary for 2AX0
Entry DOI | 10.2210/pdb2ax0/pdb |
Descriptor | Genome polyprotein, SULFATE ION, 5R-(2E-METHYL-3-PHENYL-ALLYL)-3-(BENZENESULFONYLAMINO)-4-OXO-2-THIONOTHIAZOLIDINE, ... (4 entities in total) |
Functional Keywords | hcv, ns5b, polymerase, fingers, thumb, palm, transferase |
Biological source | Hepatitis C virus |
Cellular location | Core protein p21: Host endoplasmic reticulum membrane; Single-pass membrane protein. Core protein p19: Virion (By similarity). Envelope glycoprotein E1: Virion membrane; Single-pass type I membrane protein (Potential). Envelope glycoprotein E2: Virion membrane; Single-pass type I membrane protein (Potential). p7: Host endoplasmic reticulum membrane; Multi-pass membrane protein (By similarity). Protease NS2-3: Host endoplasmic reticulum membrane; Multi-pass membrane protein (Potential). Serine protease NS3: Host endoplasmic reticulum membrane; Peripheral membrane protein (By similarity). Non-structural protein 4A: Host endoplasmic reticulum membrane; Single-pass type I membrane protein (Potential). Non-structural protein 4B: Host endoplasmic reticulum membrane; Multi-pass membrane protein (By similarity). Non-structural protein 5A: Host endoplasmic reticulum membrane; Peripheral membrane protein (By similarity). RNA-directed RNA polymerase: Host endoplasmic reticulum membrane; Single-pass type I membrane protein (Potential): P26663 |
Total number of polymer chains | 2 |
Total formula weight | 130785.68 |
Authors | Powers, J.P.,Piper, D.E.,Li, Y.,Mayorga, V.,Anzola, J.,Chen, J.M.,Jaen, J.C.,Lee, G.,Liu, J.,Peterson, M.G.,Tonn, G.R.,Ye, Q.,Walker, N.P.,Wang, Z. (deposition date: 2005-09-02, release date: 2006-01-24, Last modification date: 2021-10-20) |
Primary citation | Powers, J.P.,Piper, D.E.,Li, Y.,Mayorga, V.,Anzola, J.,Chen, J.M.,Jaen, J.C.,Lee, G.,Liu, J.,Peterson, M.G.,Tonn, G.R.,Ye, Q.,Walker, N.P.,Wang, Z. SAR and Mode of Action of Novel Non-Nucleoside Inhibitors of Hepatitis C NS5b RNA Polymerase. J.Med.Chem., 49:1034-1046, 2006 Cited by PubMed: 16451069DOI: 10.1021/jm050859x PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
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