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2AX0

Hepatitis C Virus NS5b RNA Polymerase in complex with a covalent inhibitor (5x)

Functional Information from GO Data
ChainGOidnamespacecontents
A0003723molecular_functionRNA binding
A0003968molecular_functionRNA-dependent RNA polymerase activity
A0039694biological_processviral RNA genome replication
B0003723molecular_functionRNA binding
B0003968molecular_functionRNA-dependent RNA polymerase activity
B0039694biological_processviral RNA genome replication
Functional Information from PDB Data
site_idAC1
Number of Residues4
DetailsBINDING SITE FOR RESIDUE SO4 A 1101
ChainResidue
AARG48
ALYS51
ACYS223
AHOH1173

site_idAC2
Number of Residues5
DetailsBINDING SITE FOR RESIDUE SO4 A 1102
ChainResidue
AARG510
AARG514
AHOH1222
BHOH1296
BHOH1468

site_idAC3
Number of Residues4
DetailsBINDING SITE FOR RESIDUE SO4 A 1103
ChainResidue
AARG505
AVAL530
ALYS531
ATHR532

site_idAC4
Number of Residues6
DetailsBINDING SITE FOR RESIDUE SO4 B 1104
ChainResidue
BARG48
BLYS51
BARG158
BARG222
BCYS223
BHOH1202

site_idAC5
Number of Residues5
DetailsBINDING SITE FOR RESIDUE SO4 B 1105
ChainResidue
ASER1
AHOH1279
BARG510
BARG514
BHOH1290

site_idAC6
Number of Residues4
DetailsBINDING SITE FOR RESIDUE SO4 B 1106
ChainResidue
BARG505
BVAL530
BLYS531
BTHR532

site_idAC7
Number of Residues3
DetailsBINDING SITE FOR RESIDUE SO4 B 1107
ChainResidue
BHIS475
BSER476
BHOH1412

site_idAC8
Number of Residues13
DetailsBINDING SITE FOR RESIDUE 5X A 1001
ChainResidue
APHE193
APRO197
AASN316
ACYS366
ASER368
AASN411
AMET414
ATYR415
AGLN446
AILE447
ATYR448
ASER556
AHOH1463

site_idAC9
Number of Residues14
DetailsBINDING SITE FOR RESIDUE 5X B 1002
ChainResidue
BPHE193
BPRO197
BASN316
BCYS366
BSER368
BGLY410
BASN411
BMET414
BTYR415
BGLN446
BILE447
BTYR448
BSER556
BHOH1463

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues6
DetailsBINDING: BINDING => ECO:0000305|PubMed:10557268, ECO:0000305|PubMed:11884572
ChainResidueDetails
ATHR221
AASP319
ALEU320
BTHR221
BASP319
BLEU320

site_idSWS_FT_FI2
Number of Residues2
DetailsSITE: Cleavage; by serine protease/helicase NS3 => ECO:0000250|UniProtKB:P27958
ChainResidueDetails
ASER1
BSER1

site_idSWS_FT_FI3
Number of Residues4
DetailsMOD_RES: Phosphoserine; by host => ECO:0000250|UniProtKB:P26662
ChainResidueDetails
ALEU30
AARG43
BLEU30
BARG43

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PDB entries from 2024-11-06

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