2AV7

Crystal structure of HTLV-1 TAX peptide Bound to Human Class I MHC HLA-A2 with the K66A mutation in the heavy chain.

2AV7 の概要

• エントリーDOI: 10.2210/pdb2av7/pdb
• 関連するPDBエントリー: 1DUY 1DUZ 2AV1
• 分子名称: HLA class I histocompatibility antigen, A-2 alpha chain, Beta-2-microglobulin, Trans-activating transcriptional regulatory peptide, ... (5 entities in total)
• 機能のキーワード: tax peptide, mhc, mutated hla-a2, k66a., immune system
• 由来する生物種: Homo sapiens (human); 詳細
• 細胞内の位置: Membrane; Single-pass type I membrane protein: P01892; Secreted: P61769; Host nucleus (By similarity): P14079
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 91333.35

構造登録者

Borbulevych, O.Y.,Baker, B.M. (登録日: 2005-08-29, 公開日: 2005-10-18, 最終更新日: 2023-08-23)

• 主引用文献: Gagnon, S.J.,Borbulevych, O.Y.,Davis-Harrison, R.L.,Baxter, T.K.,Clemens, J.R.,Armstrong, K.M.,Turner, R.V.,Damirjian, M.,Biddison, W.E.,Baker, B.M.; Unraveling a Hotspot for TCR Recognition on HLA-A2: Evidence Against the Existence of Peptide-independent TCR Binding Determinants.; J.Mol.Biol., 353:556-573, 2005; PubMed: 16197958; DOI: 10.1016/j.jmb.2005.08.024

実験手法

X-RAY DIFFRACTION (2.05 Å)