2AV7
Crystal structure of HTLV-1 TAX peptide Bound to Human Class I MHC HLA-A2 with the K66A mutation in the heavy chain.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, D (A, D) | HLA class I histocompatibility antigen, A-2 alpha chain | polymer | 275 | 31796.1 | 2 | UniProt (P01892) Pfam (PF00129) Pfam (PF07654) UniProt (by SIFTS) (P04439) | Homo sapiens (human) | MHC class I antigen A*2 |
| 2 | B, E (B, E) | Beta-2-microglobulin | polymer | 100 | 11879.4 | 2 | UniProt (P61769) Pfam (PF07654) | Homo sapiens (human) | |
| 3 | C, F (C, F) | Trans-activating transcriptional regulatory peptide | polymer | 9 | 1070.3 | 2 | UniProt (P14079) | Human T-cell leukemia virus 1 (isolate Caribbea HS-35 subtype A) | X-LOR protein, PX protein |
| 4 | G, H, I, J, K... (A, B, D, E, F) | GLYCEROL | non-polymer | 92.1 | 20 | Chemie (GOL) | |||
| 5 | AA, BA, CA, DA, EA... (A, B, C, D, E...) | water | water | 18.0 | 695 | Chemie (HOH) |
Sequence modifications
A, D: 1 - 275 (UniProt: P01892)
B, E: 1 - 99 (UniProt: P61769)
| PDB | External Database | Details |
|---|---|---|
| Ala 66 | Lys 90 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Met 0 | - | initiating methionine |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 89491.5 | |
| Non-Polymers* | Number of molecules | 20 |
| Total formula weight | 1841.9 | |
| All* | Total formula weight | 91333.3 |
