2AS8

Crystal structure of mature and fully active Der p 1 allergen

2AS8 の概要

• エントリーDOI: 10.2210/pdb2as8/pdb
• 分子名称: Major mite fecal allergen Der p 1, MAGNESIUM ION (3 entities in total)
• 機能のキーワード: cysteine proteinase fold, hydrolase
• 由来する生物種: Dermatophagoides pteronyssinus (European house dust mite)
• 細胞内の位置: Secreted: P08176
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 50106.27

構造登録者

de Halleux, S.,Stura, E.,VanderElst, L.,Carlier, V.,Jacquemin, M.,Saint-Remy, J.-M. (登録日: 2005-08-23, 公開日: 2005-12-06, 最終更新日: 2024-10-30)

主引用文献

de Halleux, S.,Stura, E.,VanderElst, L.,Carlier, V.,Jacquemin, M.,Saint-Remy, J.-M.
Three-dimensional structure and IgE-binding properties of mature fully active Der p 1, a clinically relevant major allergen
J.Allergy Clin.Immunol., 117:571-576, 2006

PubMed Abstract: Der p 1 is a 25-kd allergen with cysteine protease activity. Sensitization to Der p 1 affects a large proportion of individuals with allergy, resulting in rhinitis, asthma, and/or atopic dermatitis.

PubMed: 16522455
DOI: 10.1016/j.jaci.2005.11.032

実験手法

X-RAY DIFFRACTION (1.95 Å)