2ARY

Catalytic domain of Human Calpain-1

Summary for 2ARY

• Entry DOI: 10.2210/pdb2ary/pdb
• Descriptor: Calpain-1 catalytic subunit, CALCIUM ION, BETA-MERCAPTOETHANOL, ... (4 entities in total)
• Functional Keywords: cysteine protease, papain, calcium-dependent, thiol protease, hydrolase, structural genomics consortium, sgc
• Biological source: Homo sapiens (human)
• Cellular location: Cytoplasm (By similarity): P07384
• Total number of polymer chains: 2
• Total formula weight: 79551.64

Authors

Walker, J.R.,Davis, T.,Lunin, V.,Newman, E.M.,Mackenzie, F.,Weigelt, J.,Sundstrom, M.,Arrowsmith, C.,Edwards, A.,Bochkarev, A.,Dhe-Paganon, S.,Structural Genomics Consortium (SGC) (deposition date: 2005-08-22, release date: 2005-08-30, Last modification date: 2023-08-23)

• Primary citation: Davis, T.L.,Walker, J.R.,Finerty, P.J.,Mackenzie, F.,Newman, E.M.,Dhe-Paganon, S.; The Crystal Structures of Human Calpains 1 and 9 Imply Diverse Mechanisms of Action and Auto-inhibition; J.Mol.Biol., 366:216-229, 2007; PubMed: 17157313; DOI: 10.1016/j.jmb.2006.11.037

Experimental method

X-RAY DIFFRACTION (2.4 Å)