2AQK

Crystal structure of Isoniazid-resistant S94A Enoyl-ACP(CoA) reductase mutant enzyme from Mycobacterium tuberculosis in complex with NADH

Summary for 2AQK

Entry DOI	10.2210/pdb2aqk/pdb
Related	1ENY 1ENZ 2AQH 2AQI
Descriptor	Enoyl-[acyl-carrier-protein] reductase [NADH], 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE (3 entities in total)
Functional Keywords	enoyl-acyl carrier protein, oxidoreductase
Biological source	Mycobacterium tuberculosis
Total number of polymer chains	1
Total formula weight	29204.22
Authors	Oliveira, J.S.,Pereira, J.H.,Rodrigues, N.C.,Canduri, F.,de Souza, O.N.,Basso, L.A.,de Azevedo Jr., W.F.,Santos, D.S. (deposition date: 2005-08-18, release date: 2006-05-23, Last modification date: 2021-11-10)
Primary citation	Oliveira, J.S.,Pereira, J.H.,Canduri, F.,Rodrigues, N.C.,de Souza, O.N.,de Azevedo Jr., W.F.,Basso, L.A.,Santos, D.S. Crystallographic and Pre-steady-state Kinetics Studies on Binding of NADH to Wild-type and Isoniazid-resistant Enoyl-ACP(CoA) Reductase Enzymes from Mycobacterium tuberculosis. J.Mol.Biol., 359:646-666, 2006 Cited by PubMed: 16647717 DOI: 10.1016/j.jmb.2006.03.055 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.3 Å)

Structure validation