2AOW

Histamine Methyltransferase (Natural Variant I105) Complexed with the Acetylcholinesterase Inhibitor and Altzheimer's Disease Drug Tacrine

Summary for 2AOW

Entry DOI	10.2210/pdb2aow/pdb
Related	1JQD 1JQE 2AOT 2AOU 2AOV 2AOX
Descriptor	Histamine N-methyltransferase, TACRINE (3 entities in total)
Functional Keywords	classic methyltransferase fold, protein-drug complex, transferase
Biological source	Homo sapiens (human)
Cellular location	Cytoplasm: P50135
Total number of polymer chains	2
Total formula weight	67086.67
Authors	Horton, J.R.,Sawada, K.,Nishibori, M.,Cheng, X. (deposition date: 2005-08-14, release date: 2005-09-13, Last modification date: 2023-08-23)
Primary citation	Horton, J.R.,Sawada, K.,Nishibori, M.,Cheng, X. Structural basis for inhibition of histamine N-methyltransferase by diverse drugs J.Mol.Biol., 353:334-344, 2005 Cited by PubMed: 16168438 DOI: 10.1016/j.jmb.2005.08.040 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.97 Å)

Structure validation