2AOW
Histamine Methyltransferase (Natural Variant I105) Complexed with the Acetylcholinesterase Inhibitor and Altzheimer's Disease Drug Tacrine
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B | Histamine N-methyltransferase | polymer | 292 | 33345.1 | 2 | UniProt (P50135) Pfam (PF13489) In PDB | Homo sapiens (human) | HMT |
| 2 | A, B | TACRINE | non-polymer | 198.3 | 2 | Chemie (THA) | |||
| 3 | water | water | 18.0 | 25 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 292 (UniProt: P50135)
| PDB | External Database | Details |
|---|---|---|
| Ile 105 | Thr 105 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 66690.1 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 396.5 | |
| All* | Total formula weight | 67086.7 |
