2AOW

Histamine Methyltransferase (Natural Variant I105) Complexed with the Acetylcholinesterase Inhibitor and Altzheimer's Disease Drug Tacrine

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Histamine N-methyltransferase	polymer	292	33345.1	2	UniProt (P50135) Pfam (PF13489)	Homo sapiens (human)	HMT
2	C, D (A, B)	TACRINE	non-polymer		198.3	2	Chemie (THA)
3	E, F (A, B)	water	water		18.0	25	Chemie (HOH)

Sequence modifications

A, B: 1 - 292 (UniProt: P50135)

PDB	External Database	Details
Ile 105	Thr 105	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	66690.1
Non-Polymers*	Number of molecules	2
	Total formula weight	396.5
All*	Total formula weight	67086.7

*Water molecules are not included.