2AN5
Structure of human PNMT complexed with S-adenosyl-homocysteine and an inhibitor, trans-(1S,2S)-2-amino-1-tetralol
Summary for 2AN5
Entry DOI | 10.2210/pdb2an5/pdb |
Related | 1HNN 1N7I 1N7J 1YZ3 2AN3 2AN4 |
Descriptor | Phenylethanolamine N-methyltransferase, S-ADENOSYL-L-HOMOCYSTEINE, TRANS-(1S,2S)-2-AMINO-1,2,3,4-TETRAHYDRONAPHTHALEN-1-OL, ... (5 entities in total) |
Functional Keywords | methyltransferase, inhibitor structure, s-adenosyl-l-methionine, adrenaline synthesis, transferase |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 2 |
Total formula weight | 64882.16 |
Authors | Gee, C.L.,Tyndall, J.D.A.,Grunewald, G.L.,Wu, Q.,McLeish, M.J.,Martin, J.L. (deposition date: 2005-08-11, release date: 2006-03-14, Last modification date: 2023-10-25) |
Primary citation | Gee, C.L.,Tyndall, J.D.A.,Grunewald, G.L.,Wu, Q.,McLeish, M.J.,Martin, J.L. Mode of binding of methyl acceptor substrates to the adrenaline-synthesizing enzyme phenylethanolamine N-methyltransferase: implications for catalysis Biochemistry, 44:16875-16885, 2005 Cited by PubMed: 16363801DOI: 10.1021/bi051636b PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.5 Å) |
Structure validation
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