2AN5

Structure of human PNMT complexed with S-adenosyl-homocysteine and an inhibitor, trans-(1S,2S)-2-amino-1-tetralol

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	Phenylethanolamine N-methyltransferase	polymer	289	31846.0	2	UniProt (P11086) Pfam (PF01234) In PDB	Homo sapiens (human)	PNMTase, Noradrenaline N-methyltransferase
2	A, B	S-ADENOSYL-L-HOMOCYSTEINE	non-polymer		384.4	2	Chemie (SAH)
3	A, B	TRANS-(1S,2S)-2-AMINO-1,2,3,4-TETRAHYDRONAPHTHALEN-1-OL	non-polymer		163.2	2	Chemie (TTL)
4	B	PHOSPHATE ION	non-polymer		95.0	1	Chemie (PO4)
5		water	water		18.0	172	Chemie (HOH)

Sequence modifications

A, B: 1 - 282 (UniProt: P11086)

PDB	External Database	Details
Glu 283	-	expression tag
His 284	-	expression tag
His 285	-	expression tag
His 286	-	expression tag
His 287	-	expression tag
His 288	-	expression tag
His 289	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	63691.9
Non-Polymers*	Number of molecules	5
	Total formula weight	1190.2
All*	Total formula weight	64882.2

*Water molecules are not included.