2AGT
Aldose Reductase Mutant Leu 300 Pro complexed with Fidarestat
Summary for 2AGT
Entry DOI | 10.2210/pdb2agt/pdb |
Related | 1PWM |
Descriptor | Aldose reductase, CHLORIDE ION, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... (6 entities in total) |
Functional Keywords | oxidoreductase, nadp, fidarestat |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm: P15121 |
Total number of polymer chains | 1 |
Total formula weight | 37414.78 |
Authors | Petrova, T.,Steuber, H.,Hazemann, I.,Cousido-Siah, A.,Mitschler, A.,Chung, R.,Oka, M.,Klebe, G.,El-Kabbani, O.,Joachimiak, A.,Podjarny, A. (deposition date: 2005-07-27, release date: 2005-09-20, Last modification date: 2023-08-23) |
Primary citation | Petrova, T.,Steuber, H.,Hazemann, I.,Cousido-Siah, A.,Mitschler, A.,Chung, R.,Oka, M.,Klebe, G.,El-Kabbani, O.,Joachimiak, A.,Podjarny, A. Factorizing Selectivity Determinants of Inhibitor Binding toward Aldose and Aldehyde Reductases: Structural and Thermodynamic Properties of the Aldose Reductase Mutant Leu300Pro-Fidarestat Complex J.Med.Chem., 48:5659-5665, 2005 Cited by PubMed: 16134934DOI: 10.1021/jm050424+ PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1 Å) |
Structure validation
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