2AB2
Mineralocorticoid Receptor Double Mutant with Bound Spironolactone
Summary for 2AB2
Entry DOI | 10.2210/pdb2ab2/pdb |
Related | 2AA2 2AA5 2AA6 2AA7 2AAX |
Descriptor | Mineralocorticoid receptor, SPIRONOLACTONE, SULFATE ION, ... (4 entities in total) |
Functional Keywords | mineralocorticoid receptor, mr, nuclear receptor, steroid receptor, spironolactone, hypertension, transcription |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm: P08235 |
Total number of polymer chains | 2 |
Total formula weight | 64202.41 |
Authors | Bledsoe, R.K.,Madauss, K.P.,Holt, J.A.,Apolito, C.J.,Lambert, M.H.,Pearce, K.H.,Stanley, T.B.,Stewart, E.L.,Trump, R.P.,Willson, T.M.,Williams, S.P. (deposition date: 2005-07-14, release date: 2005-07-26, Last modification date: 2024-02-14) |
Primary citation | Bledsoe, R.K.,Madauss, K.P.,Holt, J.A.,Apolito, C.J.,Lambert, M.H.,Pearce, K.H.,Stanley, T.B.,Stewart, E.L.,Trump, R.P.,Willson, T.M.,Williams, S.P. A Ligand-mediated Hydrogen Bond Network Required for the Activation of the Mineralocorticoid Receptor J.Biol.Chem., 280:31283-31293, 2005 Cited by PubMed: 15967794DOI: 10.1074/jbc.M504098200 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.85 Å) |
Structure validation
Download full validation report