2AB2
Mineralocorticoid Receptor Double Mutant with Bound Spironolactone
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Mineralocorticoid receptor | polymer | 275 | 31636.6 | 2 | UniProt (P08235) Pfam (PF00104) | Homo sapiens (human) | MR |
| 2 | C, E (A, B) | SPIRONOLACTONE | non-polymer | 416.6 | 2 | Chemie (SNL) PubChem (16757735) PubChem (18594034) PubChem (24867532) PubChem (24884066) PubChem (44268286) PubChem (44280002) PubChem (50937095) PubChem (16394537) PubChem (53316433) PubChem (1742267) PubChem (1742266) PubChem (54670637) PubChem (53485777) PubChem (59105084) PubChem (5833) PubChem (58649021) PubChem (1255733) PubChem (1425524) PubChem (59078570) PubChem (59106600) PubChem (117072388) PubChem (60108251) PubChem (60113353) PubChem (7058140) PubChem (124303478) PubChem (124304402) PubChem (124900200) PubChem (129010254) PubChem (11869579) PubChem (73896881) PubChem (76974557) PubChem (5267) PubChem (89555390) PubChem (138756141) PubChem (90660429) PubChem (100923457) PubChem (941624) PubChem (122680945) PubChem (124304445) PubChem (124746581) PubChem (124900199) PubChem (6093165) PubChem (6419955) PubChem (6432512) PubChem (6604008) PubChem (129009897) PubChem (6604182) PubChem (6710654) PubChem (7061088) PubChem (7061090) PubChem (131698401) PubChem (10477021) PubChem (11509929) PubChem (11863525) PubChem (11869418) PubChem (11869419) PubChem (11869420) PubChem (11869578) PubChem (11869580) PubChem (11957686) PubChem (139421976) PubChem (12358364) PubChem (154731467) | |||
| 3 | D (B) | SULFATE ION | non-polymer | 96.1 | 1 | Chemie (SO4) | |||
| 4 | F, G (A, B) | water | water | 18.0 | 429 | Chemie (HOH) |
Sequence modifications
A, B: 712 - 984 (UniProt: P08235)
| PDB | External Database | Details |
|---|---|---|
| Gly 710 | - | cloning artifact |
| Ser 711 | - | cloning artifact |
| Ser 808 | Cys 808 | engineered mutation |
| Leu 810 | Ser 810 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 63273.2 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 929.2 | |
| All* | Total formula weight | 64202.4 |
