2AB2
Mineralocorticoid Receptor Double Mutant with Bound Spironolactone
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Mineralocorticoid receptor | polymer | 275 | 31636.6 | 2 | UniProt (P08235) Pfam (PF00104) | Homo sapiens (human) | MR |
| 2 | C, E (A, B) | SPIRONOLACTONE | non-polymer | 416.6 | 2 | Chemie (SNL) | |||
| 3 | D (B) | SULFATE ION | non-polymer | 96.1 | 1 | Chemie (SO4) | |||
| 4 | F, G (A, B) | water | water | 18.0 | 429 | Chemie (HOH) |
Sequence modifications
A, B: 712 - 984 (UniProt: P08235)
| PDB | External Database | Details |
|---|---|---|
| Gly 710 | - | cloning artifact |
| Ser 711 | - | cloning artifact |
| Ser 808 | Cys 808 | engineered mutation |
| Leu 810 | Ser 810 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 63273.2 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 929.2 | |
| All* | Total formula weight | 64202.4 |
