2AB2
Mineralocorticoid Receptor Double Mutant with Bound Spironolactone
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 B 501 |
| Chain | Residue |
| A | HOH102 |
| A | PRO759 |
| A | ASP760 |
| B | SER756 |
| B | SER757 |
| B | LYS953 |
| site_id | AC2 |
| Number of Residues | 15 |
| Details | BINDING SITE FOR RESIDUE SNL A 502 |
| Chain | Residue |
| A | ALA773 |
| A | GLN776 |
| A | MET807 |
| A | LEU810 |
| A | ARG817 |
| A | PHE829 |
| A | MET845 |
| A | MET852 |
| A | PHE941 |
| A | CYS942 |
| A | THR945 |
| A | PHE956 |
| A | LEU766 |
| A | LEU769 |
| A | ASN770 |
| site_id | AC3 |
| Number of Residues | 15 |
| Details | BINDING SITE FOR RESIDUE SNL B 503 |
| Chain | Residue |
| B | LEU766 |
| B | LEU769 |
| B | ASN770 |
| B | ALA773 |
| B | GLN776 |
| B | MET807 |
| B | LEU810 |
| B | ARG817 |
| B | PHE829 |
| B | MET845 |
| B | MET852 |
| B | PHE941 |
| B | CYS942 |
| B | THR945 |
| B | PHE956 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 6 |
| Details | Region: {"description":"Important for coactivator binding"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 6 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"15908963","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15967794","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1YA3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2AA5","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2AA6","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"15967794","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2AA5","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2AA6","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
