2AAQ

Crystal Structure Analysis of the human Glutahione Reductase, complexed with GoPI

Summary for 2AAQ

• Entry DOI: 10.2210/pdb2aaq/pdb
• Descriptor: glutathione reductase, PHOSPHATE ION, CHLORIDE ION, ... (9 entities in total)
• Functional Keywords: disulfide reductase, homodimer, antioxidative system, glutathione reduction, gold-coordination, protein gold complex, oxidoreductase
• Biological source: Homo sapiens (human)
• Cellular location: Isoform Mitochondrial: Mitochondrion. Isoform Cytoplasmic: Cytoplasm: P00390
• Total number of polymer chains: 1
• Total formula weight: 54138.14

Authors

Urig, S.,Fritz-Wolf, K.,Reau, R.,Herold-Mende, C.,Toth, K.,Davioud-Charvet, E.,Becker, K. (deposition date: 2005-07-14, release date: 2006-04-04, Last modification date: 2024-10-30)

• Primary citation: Urig, S.,Fritz-Wolf, K.,Reau, R.,Herold-Mende, C.,Toth, K.,Davioud-Charvet, E.,Becker, K.; Undressing of Phosphine Gold(I) Complexes as Irreversible Inhibitors of Human Disulfide Reductases.; Angew.Chem.Int.Ed.Engl., 45:1881-1886, 2006; PubMed: 16493712; DOI: 10.1002/anie.200502756

Experimental method

X-RAY DIFFRACTION (2.6 Å)