2A91

Crystal structure of ErbB2 domains 1-3

2A91 の概要

• エントリーDOI: 10.2210/pdb2a91/pdb
• 分子名称: Receptor tyrosine-protein kinase erbB-2, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (4 entities in total)
• 機能のキーワード: tyrosine kinase receptor; cell-surface receptor, signaling protein, transferase, membrane protein
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 57860.27

構造登録者

Garrett, T.P.J.,McKern, N.M.,Lou, M.,Elleman, T.C.,Adams, T.E.,Lovrecz, G.O.,Kofler, M.,Jorissen, R.N.,Nice, E.C.,Burgess, A.W. (登録日: 2005-07-11, 公開日: 2005-07-26, 最終更新日: 2024-10-16)

主引用文献

Garrett, T.P.J.,McKern, N.M.,Lou, M.,Elleman, T.C.,Adams, T.E.,Lovrecz, G.O.,Kofler, M.,Jorissen, R.N.,Nice, E.C.,Burgess, A.W.
The Crystal Structure of a Truncated ErbB2 Ectodomain Reveals an Active Conformation, Poised to Interact with Other ErbB Receptors
Mol.Cell, 11:495-505, 2003

PubMed Abstract: ErbB2 does not bind ligand, yet appears to be the major signaling partner for other ErbB receptors by forming heteromeric complexes with ErbB1, ErbB3, or ErbB4. The crystal structure of residues 1-509 of ErbB2 at 2.5 A resolution reveals an activated conformation similar to that of the EGFR when complexed with ligand and very different from that seen in the unactivated forms of ErbB3 or EGFR. The structure explains the inability of ErbB2 to bind known ligands and suggests why ErbB2 fails to form homodimers. Together, the data suggest a model in which ErbB2 is already in the activated conformation and ready to interact with other ligand-activated ErbB receptors.

PubMed: 12620236
DOI: 10.1016/S1097-2765(03)00048-0

実験手法

X-RAY DIFFRACTION (2.5 Å)