2A7Q
Crystal structure of human dCK complexed with clofarabine and ADP
Summary for 2A7Q
Entry DOI | 10.2210/pdb2a7q/pdb |
Related | 1P5Z 1p60 1p61 1p62 |
Descriptor | Deoxycytidine kinase, MAGNESIUM ION, ADENOSINE-5'-DIPHOSPHATE, ... (5 entities in total) |
Functional Keywords | alpha/beta parallel beta-sheet of 5 strands, transferase |
Biological source | Homo sapiens (human) |
Cellular location | Nucleus: P27707 |
Total number of polymer chains | 1 |
Total formula weight | 31589.96 |
Authors | Zhang, Y.,Secrist III, J.A.,Ealick, S.E. (deposition date: 2005-07-05, release date: 2006-01-24, Last modification date: 2023-08-23) |
Primary citation | Zhang, Y.,Secrist, J.A.,Ealick, S.E. The structure of human deoxycytidine kinase in complex with clofarabine reveals key interactions for prodrug activation. Acta Crystallogr.,Sect.D, 62:133-139, 2006 Cited by PubMed: 16421443DOI: 10.1107/S0907444905034293 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.55 Å) |
Structure validation
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