2A75
Trypanosoma rangeli Sialidase In Complex With 2,3- Difluorosialic Acid (Covalent Intermediate)
Summary for 2A75
Entry DOI | 10.2210/pdb2a75/pdb |
Related | 1N1S 2AGS 2AH2 |
Descriptor | sialidase, SULFATE ION, 5-acetamido-3,5-dideoxy-3-fluoro-D-erythro-alpha-L-manno-non-2-ulopyranosonic acid, ... (4 entities in total) |
Functional Keywords | beta-propeller, covalent enzyme-intermediate complex, beta-sandwich, hydrolase |
Biological source | Trypanosoma rangeli |
Total number of polymer chains | 1 |
Total formula weight | 71724.59 |
Authors | Amaya, M.F.,Alzari, P.M.,Buschiazzo, A. (deposition date: 2005-07-04, release date: 2005-11-22, Last modification date: 2023-08-23) |
Primary citation | Watts, A.G.,Oppezzo, P.,Withers, S.G.,Alzari, P.M.,Buschiazzo, A. Structural and Kinetic Analysis of Two Covalent Sialosyl-Enzyme Intermediates on Trypanosoma rangeli Sialidase. J.Biol.Chem., 281:4149-4155, 2006 Cited by PubMed: 16298994DOI: 10.1074/jbc.M510677200 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.95 Å) |
Structure validation
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