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2A64

Crystal Structure of Bacterial Ribonuclease P RNA

Summary for 2A64
Entry DOI10.2210/pdb2a64/pdb
Descriptorribonuclease P RNA (1 entity in total)
Functional Keywordshydrolase, ribonuclease, ribozyme, rna
Total number of polymer chains1
Total formula weight135304.17
Authors
Kazantsev, A.V.,Krivenko, A.A.,Harrington, D.J.,Holbrook, S.R.,Adams, P.D.,Pace, N.R. (deposition date: 2005-07-01, release date: 2005-09-20, Last modification date: 2024-02-14)
Primary citationKazantsev, A.V.,Krivenko, A.A.,Harrington, D.J.,Holbrook, S.R.,Adams, P.D.,Pace, N.R.
Crystal structure of a bacterial ribonuclease P RNA.
Proc.Natl.Acad.Sci.Usa, 102:13392-13397, 2005
Cited by
PubMed Abstract: The x-ray crystal structure of a 417-nt ribonuclease P RNA from Bacillus stearothermophilus was solved to 3.3-A resolution. This RNA enzyme is constructed from a number of coaxially stacked helical domains joined together by local and long-range interactions. These helical domains are arranged to form a remarkably flat surface, which is implicated by a wealth of biochemical data in the binding and cleavage of the precursors of transfer RNA substrate. Previous photoaffinity crosslinking data are used to position the substrate on the crystal structure and to identify the chemically active site of the ribozyme. This site is located in a highly conserved core structure formed by intricately interlaced long-range interactions between interhelical sequences.
PubMed: 16157868
DOI: 10.1073/pnas.0506662102
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (3.3 Å)
Structure validation

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