2A4R

HCV NS3 Protease Domain with a Ketoamide Inhibitor Covalently bound.

2A4R の概要

関連するPDBエントリー1A1R 2A4G 1JXP 1N1L 1NS3 1RTL
分子名称NS3 protease/helicase, Ns4a peptide, ZINC ION, ... (5 entities in total)
機能のキーワードviral protein
由来する生物種Hepatitis C virus
詳細
ポリマー鎖数4
分子量合計48083.16
構造登録者
Bogen, S.,Saksena, A.K.,Arasappan, A.,Gu, H.,Njoroge, F.G.,Girijavallabhan, V.,Pichardo, J.,Butkiewicz, N.,Prongay, A.,Madison, V. (登録日: 2005-06-29, 公開日: 2006-07-04, 最終更新日: 2011-07-13)
主引用文献
Bogen, S.,Saksena, A.K.,Arasappan, A.,Gu, H.,Njoroge, F.G.,Girijavallabhan, V.,Pichardo, J.,Butkiewicz, N.,Prongay, A.,Madison, V.
Hepatitis C Virus NS3-4A serine protease inhibitors: Use of a P2-P1 cyclopropyl alanine combination for improved potency.
Bioorg.Med.Chem.Lett., 15:4515-4519, 2005
PubMed: 16112862 (主引用文献が同じPDBエントリー)
DOI: 10.1016/j.bmcl.2005.07.009
MImport into Mendeley
実験手法
X-RAY DIFFRACTION (2.4 Å)
NMR情報
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構造検証レポート

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.217110.3%9.0%1.9%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
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