2A49
Crystal structure of clavulanic acid bound to E166A variant of SHV-1 beta-lactamase
Summary for 2A49
Entry DOI | 10.2210/pdb2a49/pdb |
Related | 1rcj 2A3U |
Descriptor | Beta-lactamase SHV-1, N-(2-HYDROXY-4-OXO-BUTYL)-N-(3-OXO-TRANSPROPENYL)AMINE, CYCLOHEXYL-HEXYL-BETA-D-MALTOSIDE, ... (5 entities in total) |
Functional Keywords | beta-lactamase, beta-lactam hydrolase, penicillinase, detergent binding, inhibitor design, covalent intermediate, hydrolase |
Biological source | Klebsiella pneumoniae |
Total number of polymer chains | 1 |
Total formula weight | 30732.32 |
Authors | Padayatti, P.S.,Helfand, M.S.,Totir, M.A.,Carey, M.P.,Carey, P.R.,Bonomo, R.A.,van den Akker, F. (deposition date: 2005-06-28, release date: 2005-08-02, Last modification date: 2021-10-20) |
Primary citation | Padayatti, P.S.,Helfand, M.S.,Totir, M.A.,Carey, M.P.,Carey, P.R.,Bonomo, R.A.,van den Akker, F. High Resolution Crystal Structures of the trans-Enamine Intermediates Formed by Sulbactam and Clavulanic Acid and E166A SHV-1 {beta}-Lactamase. J.Biol.Chem., 280:34900-34907, 2005 Cited by PubMed: 16055923DOI: 10.1074/jbc.M505333200 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.43 Å) |
Structure validation
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