2A49
Crystal structure of clavulanic acid bound to E166A variant of SHV-1 beta-lactamase
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Beta-lactamase SHV-1 | polymer | 269 | 29319.6 | 1 | UniProt (P14557) Pfam (PF00144) Pfam (PF13354) UniProt (by SIFTS) (P0AD64) In PDB | Klebsiella pneumoniae | PIT-2 |
| 2 | A | N-(2-HYDROXY-4-OXO-BUTYL)-N-(3-OXO-TRANSPROPENYL)AMINE | non-polymer | 157.2 | 1 | Chemie (TEM) | |||
| 3 | A | CYCLOHEXYL-HEXYL-BETA-D-MALTOSIDE | non-polymer | 508.6 | 2 | Chemie (MA4) | |||
| 4 | A | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID | non-polymer | 238.3 | 1 | Chemie (EPE) | |||
| 5 | water | water | 18.0 | 316 | Chemie (HOH) |
Sequence modifications
A: 26 - 290 (UniProt: P14557)
| PDB | External Database | Details |
|---|---|---|
| Ala 166 | Glu 162 | engineered mutation |
| Leu 293 | - | cloning artifact |
| Met 294 | - | cloning artifact |
| Ile 295 | - | cloning artifact |
| Leu 296 | - | cloning artifact |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 29319.6 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 1412.7 | |
| All* | Total formula weight | 30732.3 |
