2A3X

Decameric crystal structure of human serum amyloid P-component bound to Bis-1,2-{[(Z)-2carboxy- 2-methyl-1,3-dioxane]- 5-yloxycarbonyl}-piperazine

Summary for 2A3X

• Entry DOI: 10.2210/pdb2a3x/pdb
• Related: 1LGN
• Descriptor: Serum amyloid P-component, CALCIUM ION, BIS-1,2-{[(Z)-2CARBOXY-2-METHYL-1,3-DIOXANE]-5-YLOXYCARBONYL}-PIPERAZINE (3 entities in total)
• Functional Keywords: multivalent ligand, serum amyloid, metal binding protein
• Biological source: Homo sapiens (human)
• Cellular location: Secreted: P02743
• Total number of polymer chains: 10
• Total formula weight: 235013.33

Authors

Ho, J.G.,Kitov, P.I.,Paszkiewicz, E.,Sadowska, J.,Bundle, D.R.,Ng, K.K. (deposition date: 2005-06-27, release date: 2005-07-26, Last modification date: 2023-08-23)

• Primary citation: Ho, J.G.,Kitov, P.I.,Paszkiewicz, E.,Sadowska, J.,Bundle, D.R.,Ng, K.K.; Ligand-assisted Aggregation of Proteins: DIMERIZATION OF SERUM AMYLOID P COMPONENT BY BIVALENT LIGANDS.; J.Biol.Chem., 280:31999-32008, 2005; PubMed: 16036920; DOI: 10.1074/jbc.M504403200

Experimental method

X-RAY DIFFRACTION (3 Å)