Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

2A3X

Decameric crystal structure of human serum amyloid P-component bound to Bis-1,2-{[(Z)-2carboxy- 2-methyl-1,3-dioxane]- 5-yloxycarbonyl}-piperazine

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0001849	molecular_function	complement component C1q complex binding
A	0002674	biological_process	negative regulation of acute inflammatory response
A	0005509	molecular_function	calcium ion binding
A	0005515	molecular_function	protein binding
A	0005576	cellular_component	extracellular region
A	0005615	cellular_component	extracellular space
A	0005634	cellular_component	nucleus
A	0006457	biological_process	protein folding
A	0006953	biological_process	acute-phase response
A	0030246	molecular_function	carbohydrate binding
A	0042802	molecular_function	identical protein binding
A	0044869	biological_process	negative regulation by host of viral exo-alpha-sialidase activity
A	0044871	biological_process	negative regulation by host of viral glycoprotein metabolic process
A	0045087	biological_process	innate immune response
A	0045656	biological_process	negative regulation of monocyte differentiation
A	0046597	biological_process	negative regulation of viral entry into host cell
A	0046790	molecular_function	virion binding
A	0046872	molecular_function	metal ion binding
A	0048525	biological_process	negative regulation of viral process
A	0051082	molecular_function	unfolded protein binding
A	0051131	biological_process	chaperone-mediated protein complex assembly
A	0061045	biological_process	negative regulation of wound healing
A	0062023	cellular_component	collagen-containing extracellular matrix
A	0070062	cellular_component	extracellular exosome
A	0072562	cellular_component	blood microparticle
A	1903016	biological_process	negative regulation of exo-alpha-sialidase activity
A	1903019	biological_process	negative regulation of glycoprotein metabolic process
B	0001849	molecular_function	complement component C1q complex binding
B	0002674	biological_process	negative regulation of acute inflammatory response
B	0005509	molecular_function	calcium ion binding
B	0005515	molecular_function	protein binding
B	0005576	cellular_component	extracellular region
B	0005615	cellular_component	extracellular space
B	0005634	cellular_component	nucleus
B	0006457	biological_process	protein folding
B	0006953	biological_process	acute-phase response
B	0030246	molecular_function	carbohydrate binding
B	0042802	molecular_function	identical protein binding
B	0044869	biological_process	negative regulation by host of viral exo-alpha-sialidase activity
B	0044871	biological_process	negative regulation by host of viral glycoprotein metabolic process
B	0045087	biological_process	innate immune response
B	0045656	biological_process	negative regulation of monocyte differentiation
B	0046597	biological_process	negative regulation of viral entry into host cell
B	0046790	molecular_function	virion binding
B	0046872	molecular_function	metal ion binding
B	0048525	biological_process	negative regulation of viral process
B	0051082	molecular_function	unfolded protein binding
B	0051131	biological_process	chaperone-mediated protein complex assembly
B	0061045	biological_process	negative regulation of wound healing
B	0062023	cellular_component	collagen-containing extracellular matrix
B	0070062	cellular_component	extracellular exosome
B	0072562	cellular_component	blood microparticle
B	1903016	biological_process	negative regulation of exo-alpha-sialidase activity
B	1903019	biological_process	negative regulation of glycoprotein metabolic process
C	0001849	molecular_function	complement component C1q complex binding
C	0002674	biological_process	negative regulation of acute inflammatory response
C	0005509	molecular_function	calcium ion binding
C	0005515	molecular_function	protein binding
C	0005576	cellular_component	extracellular region
C	0005615	cellular_component	extracellular space
C	0005634	cellular_component	nucleus
C	0006457	biological_process	protein folding
C	0006953	biological_process	acute-phase response
C	0030246	molecular_function	carbohydrate binding
C	0042802	molecular_function	identical protein binding
C	0044869	biological_process	negative regulation by host of viral exo-alpha-sialidase activity
C	0044871	biological_process	negative regulation by host of viral glycoprotein metabolic process
C	0045087	biological_process	innate immune response
C	0045656	biological_process	negative regulation of monocyte differentiation
C	0046597	biological_process	negative regulation of viral entry into host cell
C	0046790	molecular_function	virion binding
C	0046872	molecular_function	metal ion binding
C	0048525	biological_process	negative regulation of viral process
C	0051082	molecular_function	unfolded protein binding
C	0051131	biological_process	chaperone-mediated protein complex assembly
C	0061045	biological_process	negative regulation of wound healing
C	0062023	cellular_component	collagen-containing extracellular matrix
C	0070062	cellular_component	extracellular exosome
C	0072562	cellular_component	blood microparticle
C	1903016	biological_process	negative regulation of exo-alpha-sialidase activity
C	1903019	biological_process	negative regulation of glycoprotein metabolic process
D	0001849	molecular_function	complement component C1q complex binding
D	0002674	biological_process	negative regulation of acute inflammatory response
D	0005509	molecular_function	calcium ion binding
D	0005515	molecular_function	protein binding
D	0005576	cellular_component	extracellular region
D	0005615	cellular_component	extracellular space
D	0005634	cellular_component	nucleus
D	0006457	biological_process	protein folding
D	0006953	biological_process	acute-phase response
D	0030246	molecular_function	carbohydrate binding
D	0042802	molecular_function	identical protein binding
D	0044869	biological_process	negative regulation by host of viral exo-alpha-sialidase activity
D	0044871	biological_process	negative regulation by host of viral glycoprotein metabolic process
D	0045087	biological_process	innate immune response
D	0045656	biological_process	negative regulation of monocyte differentiation
D	0046597	biological_process	negative regulation of viral entry into host cell
D	0046790	molecular_function	virion binding
D	0046872	molecular_function	metal ion binding
D	0048525	biological_process	negative regulation of viral process
D	0051082	molecular_function	unfolded protein binding
D	0051131	biological_process	chaperone-mediated protein complex assembly
D	0061045	biological_process	negative regulation of wound healing
D	0062023	cellular_component	collagen-containing extracellular matrix
D	0070062	cellular_component	extracellular exosome
D	0072562	cellular_component	blood microparticle
D	1903016	biological_process	negative regulation of exo-alpha-sialidase activity
D	1903019	biological_process	negative regulation of glycoprotein metabolic process
E	0001849	molecular_function	complement component C1q complex binding
E	0002674	biological_process	negative regulation of acute inflammatory response
E	0005509	molecular_function	calcium ion binding
E	0005515	molecular_function	protein binding
E	0005576	cellular_component	extracellular region
E	0005615	cellular_component	extracellular space
E	0005634	cellular_component	nucleus
E	0006457	biological_process	protein folding
E	0006953	biological_process	acute-phase response
E	0030246	molecular_function	carbohydrate binding
E	0042802	molecular_function	identical protein binding
E	0044869	biological_process	negative regulation by host of viral exo-alpha-sialidase activity
E	0044871	biological_process	negative regulation by host of viral glycoprotein metabolic process
E	0045087	biological_process	innate immune response
E	0045656	biological_process	negative regulation of monocyte differentiation
E	0046597	biological_process	negative regulation of viral entry into host cell
E	0046790	molecular_function	virion binding
E	0046872	molecular_function	metal ion binding
E	0048525	biological_process	negative regulation of viral process
E	0051082	molecular_function	unfolded protein binding
E	0051131	biological_process	chaperone-mediated protein complex assembly
E	0061045	biological_process	negative regulation of wound healing
E	0062023	cellular_component	collagen-containing extracellular matrix
E	0070062	cellular_component	extracellular exosome
E	0072562	cellular_component	blood microparticle
E	1903016	biological_process	negative regulation of exo-alpha-sialidase activity
E	1903019	biological_process	negative regulation of glycoprotein metabolic process
F	0001849	molecular_function	complement component C1q complex binding
F	0002674	biological_process	negative regulation of acute inflammatory response
F	0005509	molecular_function	calcium ion binding
F	0005515	molecular_function	protein binding
F	0005576	cellular_component	extracellular region
F	0005615	cellular_component	extracellular space
F	0005634	cellular_component	nucleus
F	0006457	biological_process	protein folding
F	0006953	biological_process	acute-phase response
F	0030246	molecular_function	carbohydrate binding
F	0042802	molecular_function	identical protein binding
F	0044869	biological_process	negative regulation by host of viral exo-alpha-sialidase activity
F	0044871	biological_process	negative regulation by host of viral glycoprotein metabolic process
F	0045087	biological_process	innate immune response
F	0045656	biological_process	negative regulation of monocyte differentiation
F	0046597	biological_process	negative regulation of viral entry into host cell
F	0046790	molecular_function	virion binding
F	0046872	molecular_function	metal ion binding
F	0048525	biological_process	negative regulation of viral process
F	0051082	molecular_function	unfolded protein binding
F	0051131	biological_process	chaperone-mediated protein complex assembly
F	0061045	biological_process	negative regulation of wound healing
F	0062023	cellular_component	collagen-containing extracellular matrix
F	0070062	cellular_component	extracellular exosome
F	0072562	cellular_component	blood microparticle
F	1903016	biological_process	negative regulation of exo-alpha-sialidase activity
F	1903019	biological_process	negative regulation of glycoprotein metabolic process
G	0001849	molecular_function	complement component C1q complex binding
G	0002674	biological_process	negative regulation of acute inflammatory response
G	0005509	molecular_function	calcium ion binding
G	0005515	molecular_function	protein binding
G	0005576	cellular_component	extracellular region
G	0005615	cellular_component	extracellular space
G	0005634	cellular_component	nucleus
G	0006457	biological_process	protein folding
G	0006953	biological_process	acute-phase response
G	0030246	molecular_function	carbohydrate binding
G	0042802	molecular_function	identical protein binding
G	0044869	biological_process	negative regulation by host of viral exo-alpha-sialidase activity
G	0044871	biological_process	negative regulation by host of viral glycoprotein metabolic process
G	0045087	biological_process	innate immune response
G	0045656	biological_process	negative regulation of monocyte differentiation
G	0046597	biological_process	negative regulation of viral entry into host cell
G	0046790	molecular_function	virion binding
G	0046872	molecular_function	metal ion binding
G	0048525	biological_process	negative regulation of viral process
G	0051082	molecular_function	unfolded protein binding
G	0051131	biological_process	chaperone-mediated protein complex assembly
G	0061045	biological_process	negative regulation of wound healing
G	0062023	cellular_component	collagen-containing extracellular matrix
G	0070062	cellular_component	extracellular exosome
G	0072562	cellular_component	blood microparticle
G	1903016	biological_process	negative regulation of exo-alpha-sialidase activity
G	1903019	biological_process	negative regulation of glycoprotein metabolic process
H	0001849	molecular_function	complement component C1q complex binding
H	0002674	biological_process	negative regulation of acute inflammatory response
H	0005509	molecular_function	calcium ion binding
H	0005515	molecular_function	protein binding
H	0005576	cellular_component	extracellular region
H	0005615	cellular_component	extracellular space
H	0005634	cellular_component	nucleus
H	0006457	biological_process	protein folding
H	0006953	biological_process	acute-phase response
H	0030246	molecular_function	carbohydrate binding
H	0042802	molecular_function	identical protein binding
H	0044869	biological_process	negative regulation by host of viral exo-alpha-sialidase activity
H	0044871	biological_process	negative regulation by host of viral glycoprotein metabolic process
H	0045087	biological_process	innate immune response
H	0045656	biological_process	negative regulation of monocyte differentiation
H	0046597	biological_process	negative regulation of viral entry into host cell
H	0046790	molecular_function	virion binding
H	0046872	molecular_function	metal ion binding
H	0048525	biological_process	negative regulation of viral process
H	0051082	molecular_function	unfolded protein binding
H	0051131	biological_process	chaperone-mediated protein complex assembly
H	0061045	biological_process	negative regulation of wound healing
H	0062023	cellular_component	collagen-containing extracellular matrix
H	0070062	cellular_component	extracellular exosome
H	0072562	cellular_component	blood microparticle
H	1903016	biological_process	negative regulation of exo-alpha-sialidase activity
H	1903019	biological_process	negative regulation of glycoprotein metabolic process
I	0001849	molecular_function	complement component C1q complex binding
I	0002674	biological_process	negative regulation of acute inflammatory response
I	0005509	molecular_function	calcium ion binding
I	0005515	molecular_function	protein binding
I	0005576	cellular_component	extracellular region
I	0005615	cellular_component	extracellular space
I	0005634	cellular_component	nucleus
I	0006457	biological_process	protein folding
I	0006953	biological_process	acute-phase response
I	0030246	molecular_function	carbohydrate binding
I	0042802	molecular_function	identical protein binding
I	0044869	biological_process	negative regulation by host of viral exo-alpha-sialidase activity
I	0044871	biological_process	negative regulation by host of viral glycoprotein metabolic process
I	0045087	biological_process	innate immune response
I	0045656	biological_process	negative regulation of monocyte differentiation
I	0046597	biological_process	negative regulation of viral entry into host cell
I	0046790	molecular_function	virion binding
I	0046872	molecular_function	metal ion binding
I	0048525	biological_process	negative regulation of viral process
I	0051082	molecular_function	unfolded protein binding
I	0051131	biological_process	chaperone-mediated protein complex assembly
I	0061045	biological_process	negative regulation of wound healing
I	0062023	cellular_component	collagen-containing extracellular matrix
I	0070062	cellular_component	extracellular exosome
I	0072562	cellular_component	blood microparticle
I	1903016	biological_process	negative regulation of exo-alpha-sialidase activity
I	1903019	biological_process	negative regulation of glycoprotein metabolic process
J	0001849	molecular_function	complement component C1q complex binding
J	0002674	biological_process	negative regulation of acute inflammatory response
J	0005509	molecular_function	calcium ion binding
J	0005515	molecular_function	protein binding
J	0005576	cellular_component	extracellular region
J	0005615	cellular_component	extracellular space
J	0005634	cellular_component	nucleus
J	0006457	biological_process	protein folding
J	0006953	biological_process	acute-phase response
J	0030246	molecular_function	carbohydrate binding
J	0042802	molecular_function	identical protein binding
J	0044869	biological_process	negative regulation by host of viral exo-alpha-sialidase activity
J	0044871	biological_process	negative regulation by host of viral glycoprotein metabolic process
J	0045087	biological_process	innate immune response
J	0045656	biological_process	negative regulation of monocyte differentiation
J	0046597	biological_process	negative regulation of viral entry into host cell
J	0046790	molecular_function	virion binding
J	0046872	molecular_function	metal ion binding
J	0048525	biological_process	negative regulation of viral process
J	0051082	molecular_function	unfolded protein binding
J	0051131	biological_process	chaperone-mediated protein complex assembly
J	0061045	biological_process	negative regulation of wound healing
J	0062023	cellular_component	collagen-containing extracellular matrix
J	0070062	cellular_component	extracellular exosome
J	0072562	cellular_component	blood microparticle
J	1903016	biological_process	negative regulation of exo-alpha-sialidase activity
J	1903019	biological_process	negative regulation of glycoprotein metabolic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CA A 301

Chain	Residue
A	ASP58
A	ASN59
A	GLU136
A	GLN137
A	ASP138

site_id	AC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CA A 302

Chain	Residue
A	GLU136
A	ASP138
A	GLN148

site_id	AC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA B 303

Chain	Residue
B	ASN59
B	GLU136
B	GLN137
B	ASP138
B	CA304
B	ASP58

site_id	AC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CA B 304

Chain	Residue
B	GLU136
B	ASP138
B	ASP145
B	GLN148
B	CA303

site_id	AC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA C 305

Chain	Residue
C	ASP58
C	ASN59
C	GLU136
C	GLN137
C	ASP138
C	CPK402

site_id	AC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CA C 306

Chain	Residue
C	GLU136
C	ASP138
C	GLN148
C	CPK402

site_id	AC7
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA D 307

Chain	Residue
D	ASP58
D	ASN59
D	GLU136
D	GLN137
D	ASP138
I	CPK401

site_id	AC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CA D 308

Chain	Residue
D	GLU136
D	ASP138
D	GLN148
I	CPK401

site_id	AC9
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA E 309

Chain	Residue
E	ASP58
E	ASN59
E	GLU136
E	GLN137
E	ASP138
H	CPK403

site_id	BC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CA E 310

Chain	Residue
E	GLU136
E	ASP138
E	GLN148
H	CPK403

site_id	BC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CA F 311

Chain	Residue
F	ASN59
F	GLU136
F	ASP138

site_id	BC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CA F 312

Chain	Residue
F	GLU136
F	ASP138
F	LYS143
F	ASP145
F	GLN148

site_id	BC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA G 313

Chain	Residue
G	ASP58
G	ASN59
G	GLU136
G	GLN137
G	ASP138
G	CA314

site_id	BC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CA G 314

Chain	Residue
G	GLU136
G	GLN137
G	ASP138
G	ASP145
G	CA313

site_id	BC6
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA H 315

Chain	Residue
H	ASP58
H	ASN59
H	GLU136
H	GLN137
H	ASP138
H	CPK403

site_id	BC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CA H 316

Chain	Residue
H	GLU136
H	ASP138
H	GLN148
H	CPK403

site_id	BC8
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA I 317

Chain	Residue
I	ASP58
I	ASN59
I	GLU136
I	GLN137
I	ASP138
I	CPK401

site_id	BC9
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CA I 318

Chain	Residue
I	GLU136
I	ASP138
I	GLN148
I	CPK401

site_id	CC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA J 319

Chain	Residue
C	CPK402
J	ASP58
J	ASN59
J	GLU136
J	GLN137
J	ASP138

site_id	CC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CA J 320

Chain	Residue
C	CPK402
J	GLU136
J	ASP138
J	GLN148

site_id	CC3
Number of Residues	17
Details	BINDING SITE FOR RESIDUE CPK I 401

Chain	Residue
D	LEU62
D	TYR74
D	GLU136
D	ASP138
D	GLN148
D	CA307
D	CA308
I	ASP58
I	ASN59
I	LEU62
I	TYR74
I	GLU136
I	ASP138
I	GLN148
I	CA317
I	CA318
D	ASN59

site_id	CC4
Number of Residues	18
Details	BINDING SITE FOR RESIDUE CPK C 402

Chain	Residue
C	ASN59
C	LEU62
C	TYR64
C	TYR74
C	LYS79
C	GLU136
C	ASP138
C	GLN148
C	CA305
C	CA306
J	ASN59
J	LEU62
J	TYR64
J	TYR74
J	GLU136
J	GLN148
J	CA319
J	CA320

site_id	CC5
Number of Residues	16
Details	BINDING SITE FOR RESIDUE CPK H 403

Chain	Residue
E	ASN59
E	LEU62
E	TYR64
E	TYR74
E	GLU136
E	ASP138
E	GLN148
E	CA309
E	CA310
H	ASN59
H	LEU62
H	TYR74
H	GLU136
H	GLN148
H	CA315
H	CA316

Functional Information from PROSITE/UniProt

site_id	PS00289
Number of Residues	8
Details	PTX_1 Pentraxin domain signature. HiCvSWeS

Chain	Residue	Details
A	HIS93-SER100

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	60
Details	BINDING: BINDING => ECO:0000255\|PROSITE-ProRule:PRU01172

Chain	Residue	Details
A	ASP58
B	GLN137
B	ASP138
B	GLN148
C	ASP58
C	ASN59
C	GLU136
C	GLN137
C	ASP138
C	GLN148
D	ASP58
A	ASN59
D	ASN59
D	GLU136
D	GLN137
D	ASP138
D	GLN148
E	ASP58
E	ASN59
E	GLU136
E	GLN137
E	ASP138
A	GLU136
E	GLN148
F	ASP58
F	ASN59
F	GLU136
F	GLN137
F	ASP138
F	GLN148
G	ASP58
G	ASN59
G	GLU136
A	GLN137
G	GLN137
G	ASP138
G	GLN148
H	ASP58
H	ASN59
H	GLU136
H	GLN137
H	ASP138
H	GLN148
I	ASP58
A	ASP138
I	ASN59
I	GLU136
I	GLN137
I	ASP138
I	GLN148
J	ASP58
J	ASN59
J	GLU136
J	GLN137
J	ASP138
A	GLN148
J	GLN148
B	ASP58
B	ASN59
B	GLU136

site_id	SWS_FT_FI2
Number of Residues	10
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269\|PubMed:16335952, ECO:0000269\|PubMed:19159218

Chain	Residue	Details
A	ASN32
J	ASN32
B	ASN32
C	ASN32
D	ASN32
E	ASN32
F	ASN32
G	ASN32
H	ASN32
I	ASN32

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)