2A2A

High-resolution crystallographic analysis of the autoinhibited conformation of a human death-associated protein kinase

Summary for 2A2A

Entry DOI	10.2210/pdb2a2a/pdb
Related	2A27
Descriptor	Death-associated protein kinase 2, SODIUM ION, CHLORIDE ION, ... (6 entities in total)
Functional Keywords	protein kinase, autoinhibition, transferase
Biological source	Homo sapiens (human)
Cellular location	Cytoplasm: Q9UIK4
Total number of polymer chains	4
Total formula weight	149849.58
Authors	Kursula, P.,Wilmanns, M. (deposition date: 2005-06-22, release date: 2006-10-17, Last modification date: 2023-10-25)
Primary citation	Simon, B.,Huart, A.S.,Temmerman, K.,Vahokoski, J.,Mertens, H.D.,Komadina, D.,Hoffmann, J.E.,Yumerefendi, H.,Svergun, D.I.,Kursula, P.,Schultz, C.,McCarthy, A.A.,Hart, D.J.,Wilmanns, M. Death-Associated Protein Kinase Activity Is Regulated by Coupled Calcium/Calmodulin Binding to Two Distinct Sites Structure, 2016 Cited by PubMed: 27133022 DOI: 10.1016/j.str.2016.03.020 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.47 Å)

Structure validation