2A2A
High-resolution crystallographic analysis of the autoinhibited conformation of a human death-associated protein kinase
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Death-associated protein kinase 2 | polymer | 321 | 37166.5 | 4 | UniProt (Q9UIK4) Pfam (PF00069) | Homo sapiens (human) | DRP-1 kinase, DAP kinase 2, DAP- kinase related protein 1, DRP-1 |
| 2 | E, F, K, L, N... (A, B, C, D) | SODIUM ION | non-polymer | 23.0 | 8 | Chemie (NA) | |||
| 3 | G, H, Q (A, C) | CHLORIDE ION | non-polymer | 35.5 | 3 | Chemie (CL) | |||
| 4 | I, M, R, U (A, B, C, D) | 2,3-DIHYDROXY-1,4-DITHIOBUTANE | non-polymer | 154.3 | 4 | Chemie (DTT) | |||
| 5 | J, S, V (A, C, D) | GLYCEROL | non-polymer | 92.1 | 3 | Chemie (GOL) | |||
| 6 | W, X, Y, Z (A, B, C, D) | water | water | 18.0 | 1371 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 1 - 320 (UniProt: Q9UIK4)
| PDB | External Database | Details |
|---|---|---|
| Gly 0 | - | expression tag |
| Ser 231 | Ala 241 | SEE REMARK 999 |
| His 243 | Gln 253 | SEE REMARK 999 |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 148666.0 | |
| Non-Polymers* | Number of molecules | 18 |
| Total formula weight | 1183.6 | |
| All* | Total formula weight | 149849.6 |
