2A1E
High resolution structure of HIV-1 PR with TS-126
Summary for 2A1E
Entry DOI | 10.2210/pdb2a1e/pdb |
Related | 1FGC 1S6G |
Descriptor | Pol polyprotein, DIMETHYL SULFOXIDE, SODIUM ION, ... (8 entities in total) |
Functional Keywords | hiv pr, peptidomimetic inhibitor, stereoisomer, screening a mixture, hydrolase |
Biological source | Human immunodeficiency virus 1 |
Cellular location | Gag-Pol polyprotein: Host cell membrane ; Lipid-anchor. Matrix protein p17: Virion membrane; Lipid- anchor . Capsid protein p24: Virion . Nucleocapsid protein p7: Virion . Reverse transcriptase/ribonuclease H: Virion . Integrase: Virion : P03367 |
Total number of polymer chains | 2 |
Total formula weight | 23045.74 |
Authors | Demitri, N.,Geremia, S.,Randaccio, L.,Wuerges, J.,Benedetti, F.,Berti, F.,Dinon, F.,Campaner, P.,Tell, G. (deposition date: 2005-06-20, release date: 2006-02-21, Last modification date: 2023-10-25) |
Primary citation | Geremia, S.,Demitri, N.,Wuerges, J.,Benedetti, F.,Berti, F.,Tell, G.,Randaccio, L. A potent HIV protease inhibitor identified in an epimeric mixture by high-resolution protein crystallography. Chemmedchem, 1:186-188, 2006 Cited by PubMed: 16892350DOI: 10.1002/cmdc.200500063 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.3 Å) |
Structure validation
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