Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004190 | molecular_function | aspartic-type endopeptidase activity |
| A | 0006508 | biological_process | proteolysis |
| B | 0004190 | molecular_function | aspartic-type endopeptidase activity |
| B | 0006508 | biological_process | proteolysis |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE NA B 305 |
| Chain | Residue |
| A | GLN18 |
| A | LYS20 |
| A | GLU35 |
| A | MET36 |
| B | LYS14 |
| B | GLU65 |
| B | GOL304 |
| site_id | AC2 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE CL B 307 |
| site_id | AC3 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE ACT B 308 |
| Chain | Residue |
| A | TRP6 |
| B | ARG87 |
| B | THR91 |
| B | HOH436 |
| B | HOH471 |
| B | HOH505 |
| A | LEU5 |
| site_id | AC4 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE ACT B 309 |
| Chain | Residue |
| B | GLY40 |
| B | HOH442 |
| site_id | AC5 |
| Number of Residues | 25 |
| Details | BINDING SITE FOR RESIDUE IPF B 400 |
| Chain | Residue |
| A | TRP6 |
| A | ARG8 |
| A | ASP25 |
| A | GLY27 |
| A | ALA28 |
| A | ASP29 |
| A | ASP30 |
| A | ILE47 |
| A | GLY48 |
| A | ILE50 |
| A | VAL82 |
| B | ARG8 |
| B | LEU23 |
| B | ASP25 |
| B | GLY27 |
| B | ALA28 |
| B | ASP29 |
| B | ASP30 |
| B | ILE47 |
| B | GLY48 |
| B | GLY49 |
| B | ILE50 |
| B | PRO81 |
| B | ILE84 |
| B | HOH416 |
| site_id | AC6 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE DMS A 301 |
| Chain | Residue |
| A | ARG87 |
| A | ASN88 |
| A | THR91 |
| B | LEU5 |
| B | TRP6 |
| B | ARG41 |
| site_id | AC7 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE DMS A 302 |
| Chain | Residue |
| A | GLY73 |
| A | THR74 |
| A | ASN88 |
| A | HOH372 |
| B | ARG41 |
| B | HOH520 |
| site_id | AC8 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE DMS A 303 |
| Chain | Residue |
| A | GLN18 |
| A | LEU19 |
| A | LYS20 |
| B | GLU65 |
| B | GLY68 |
| B | LYS70 |
| site_id | AC9 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE DMS B 306 |
| Chain | Residue |
| B | GLU35 |
| B | LYS55 |
| B | ARG57 |
| B | VAL77 |
| B | HOH479 |
| site_id | BC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE DMS A 310 |
| Chain | Residue |
| A | THR12 |
| A | GLU65 |
| A | ILE66 |
| A | ALA67 |
| A | GLY68 |
| A | HOH344 |
| site_id | BC2 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE GOL B 304 |
| Chain | Residue |
| A | GLN18 |
| A | MET36 |
| A | SER37 |
| B | THR12 |
| B | ILE13 |
| B | LYS14 |
| B | GLU65 |
| B | ILE66 |
| B | ALA67 |
| B | GLY68 |
| B | NA305 |
Functional Information from PROSITE/UniProt
| site_id | PS00141 |
| Number of Residues | 12 |
| Details | ASP_PROTEASE Eukaryotic and viral aspartyl proteases active site. ALLDTGADDTVI |
| Chain | Residue | Details |
| A | ALA22-ILE33 | |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 138 |
| Details | Domain: {"description":"Peptidase A2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00275","evidenceCode":"ECO:0000255"}]} |
| site_id | SWS_FT_FI2 |
| Number of Residues | 20 |
| Details | Region: {"description":"Dimerization of protease","evidences":[{"source":"UniProtKB","id":"P04585","evidenceCode":"ECO:0000250"}]} |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Active site: {"description":"For protease activity; shared with dimeric partner","evidences":[{"source":"PROSITE-ProRule","id":"PRU10094","evidenceCode":"ECO:0000255"}]} |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1a30 |
| Chain | Residue | Details |
| A | ASP25 | |
| A | THR26 | |
| B | ASP25 | |
| B | THR26 | |
| site_id | CSA2 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1a30 |
| Chain | Residue | Details |
| A | ASP25 | |
| B | ASP25 | |
