2A0C

Human CDK2 in complex with olomoucine II, a novel 2,6,9-trisubstituted purine cyclin-dependent kinase inhibitor

Summary for 2A0C

Entry DOI	10.2210/pdb2a0c/pdb
Descriptor	Cell division protein kinase 2, 2-{[(2-{[(1R)-1-(HYDROXYMETHYL)PROPYL]AMINO}-9-ISOPROPYL-9H-PURIN-6-YL)AMINO]METHYL}PHENOL (3 entities in total)
Functional Keywords	protein kinase, cell cycle, phosphorylation, cell division, mitosis, inhibition, transferase, serine/threonine-protein kinase, atp-binding
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	34346.94
Authors	Krystof, V.,McNae, I.W.,Walkinshaw, M.D.,Fischer, P.M.,Muller, P.,Vojtesek, B.,Orsag, M.,Havlicek, L.,Strnad, M. (deposition date: 2005-06-16, release date: 2006-01-24, Last modification date: 2024-03-13)
Primary citation	Krystof, V.,McNae, I.W.,Walkinshaw, M.D.,Fischer, P.M.,Muller, P.,Vojtesek, B.,Orsag, M.,Havlicek, L.,Strnad, M. Antiproliferative activity of olomoucine II, a novel 2,6,9-trisubstituted purine cyclin-dependent kinase inhibitor Cell.Mol.Life Sci., 62:1763-1771, 2005 Cited by PubMed: 16003486 DOI: 10.1007/s00018-005-5185-1 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.95 Å)

Structure validation