2ZTW
Structure of 3-isopropylmalate dehydrogenase in complex with the inhibitor and NAD+
Summary for 2ZTW
Entry DOI | 10.2210/pdb2ztw/pdb |
Descriptor | 3-isopropylmalate dehydrogenase, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, (2Z)-2-hydroxy-3-(methylsulfanyl)prop-2-enoic acid, ... (5 entities in total) |
Functional Keywords | 3-isopropylmalate dehydrogenase, ipmdh, decarboxylating dehydrogenase, leucine biosynthesis, amino-acid biosynthesis, branched-chain amino acid biosynthesis, cytoplasm, magnesium, manganese, metal-binding, nad, oxidoreductase |
Biological source | Thermus thermophilus |
Cellular location | Cytoplasm: Q5SIY4 |
Total number of polymer chains | 1 |
Total formula weight | 37647.04 |
Authors | Nango, E.,Kumasaka, T.,Eguchi, T. (deposition date: 2008-10-10, release date: 2009-10-13, Last modification date: 2023-11-01) |
Primary citation | Nango, E.,Yamamoto, T.,Kumasaka, T.,Eguchi, T. Crystal structure of 3-isopropylmalate dehydrogenase in complex with NAD(+) and a designed inhibitor Bioorg.Med.Chem., 17:7789-7794, 2009 Cited by PubMed: 19833522DOI: 10.1016/j.bmc.2009.09.025 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.79 Å) |
Structure validation
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