Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000287 | molecular_function | magnesium ion binding |
| A | 0003862 | molecular_function | 3-isopropylmalate dehydrogenase activity |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0009098 | biological_process | L-leucine biosynthetic process |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| A | 0042802 | molecular_function | identical protein binding |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0051287 | molecular_function | NAD binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE NAD A 400 |
| Chain | Residue |
| A | HIS273 |
| A | GLY274 |
| A | ALA276 |
| A | ASP278 |
| A | ILE279 |
| A | ALA285 |
| A | ASN286 |
| A | HOH471 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE DEI A 401 |
| Chain | Residue |
| A | SER259 |
| A | GLU270 |
| A | VAL272 |
| A | ASN102 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE MG A 402 |
| Chain | Residue |
| A | PHE170 |
| A | GLY203 |
| A | TYR206 |
| A | VAL209 |
Functional Information from PROSITE/UniProt
| site_id | PS00470 |
| Number of Residues | 20 |
| Details | IDH_IMDH Isocitrate and isopropylmalate dehydrogenases signature. NIFGDIlSDlaSvlp.GSLGL |
| Chain | Residue | Details |
| A | ASN237-LEU256 | |
Functional Information from SwissProt/UniProt
| Chain | Residue | Details |
| A | GLY74 | |
| A | GLY274 | |
| site_id | SWS_FT_FI2 |
| Number of Residues | 6 |
| Details | BINDING: BINDING => ECO:0000250 |
| Chain | Residue | Details |
| A | ARG94 | |
| A | ARG104 | |
| A | ARG132 | |
| A | ASP217 | |
| A | ASP241 | |
| A | ASP245 | |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | SITE: Important for catalysis |
| Chain | Residue | Details |
| A | TYR139 | |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | SITE: Important for catalysis => ECO:0000250 |
| Chain | Residue | Details |
| A | LYS185 | |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1a05 |
| Chain | Residue | Details |
| A | TYR139 | |
| site_id | CSA2 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1a05 |
| Chain | Residue | Details |
| A | LYS185 | |
| A | ASP217 | |
