2ZPP

Neutron crystal structure of cubic insulin at pD9

Summary for 2ZPP
Related2EFA
DescriptorInsulin A chain, Insulin B chain (3 entities in total)
Functional Keywordshormone, cubic, porcine insulin, carbohydrate metabolism, cleavage on pair of basic residues, glucose metabolism, secreted
Biological sourceSus scrofa (Pig)
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Cellular locationSecreted: P01315 P01315
Total number of polymer chains2
Total formula weight5787.63
Authors
Ishikawa, T.,Tanaka, I.,Niimura, N. (deposition date: 2008-07-26, release date: 2008-10-28, Last modification date: 2018-03-07)
Primary citationChatake, T.,Ishikawa, T.,Kurihara, K.,Maeda, M.,Morimoto, Y.,Niimura, N.,Tanaka, I.
An abnormal pK(a) value of internal histidine of the insulin molecule revealed by neutron crystallographic analysis
Biochem.Biophys.Res.Commun., 376:32-35, 2008
PubMed: 18725203
DOI: 110.1016/j.bbrc.2008.08.071
PDB entries with the same primary citation
Experimental method
NEUTRON DIFFRACTION (2.5 Å)
Structure validation
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PDB entries from 2021-06-23