2YXJ
Crystal structure of Bcl-xL in complex with ABT-737
Summary for 2YXJ
Entry DOI | 10.2210/pdb2yxj/pdb |
Related | 1AF3 1MAZ 1PQ0 1PQ1 1R2D 1YSG 1YSI 1YSN 2O1Y 2O2M 2O2N |
Descriptor | Apoptosis regulator Bcl-X, CHLORIDE ION, 4-{4-[(4'-CHLOROBIPHENYL-2-YL)METHYL]PIPERAZIN-1-YL}-N-{[4-({(1R)-3-(DIMETHYLAMINO)-1-[(PHENYLTHIO)METHYL]PROPYL}AMINO)-3-NITROPHENYL]SULFONYL}BENZAMIDE, ... (5 entities in total) |
Functional Keywords | apoptosis, cancer therapeutic |
Biological source | Homo sapiens (human) More |
Cellular location | Isoform Bcl-X(L): Mitochondrion inner membrane : Q07817 |
Total number of polymer chains | 2 |
Total formula weight | 43364.24 |
Authors | Czabotar, P.E.,Lee, E.F.,Smith, B.J.,Deshayes, K.,Zobel, K.,Fairlie, W.D.,Colman, P.M. (deposition date: 2007-04-26, release date: 2007-05-22, Last modification date: 2023-10-25) |
Primary citation | Lee, E.F.,Czabotar, P.E.,Smith, B.J.,Deshayes, K.,Zobel, K.,Colman, P.M.,Fairlie, W.D. Crystal structure of ABT-737 complexed with Bcl-xL: implications for selectivity of antagonists of the Bcl-2 family Cell Death Differ., 14:1711-1713, 2007 Cited by PubMed: 17572662DOI: 10.1038/sj.cdd.4402178 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.2 Å) |
Structure validation
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