2XH1
Crystal structure of human KAT II-inhibitor complex
Summary for 2XH1
Entry DOI | 10.2210/pdb2xh1/pdb |
Related | 2VGZ |
Descriptor | KYNURENINE/ALPHA-AMINOADIPATE AMINOTRANSFERASE, MITOCHONDRIAL, (3S)-10-(4-AMINOPIPERAZIN-1-YL)-9-FLUORO-7-HYDROXY-3-METHYL-2,3-DIHYDRO-8H-[1,4]OXAZINO[2,3,4-IJ]QUINOLINE-6-CARBOXYLATE, PYRIDOXAL-5'-PHOSPHATE, ... (6 entities in total) |
Functional Keywords | transferase, covalent inhibition |
Biological source | HOMO SAPIENS (HUMAN) |
Cellular location | Mitochondrion (Potential): Q8N5Z0 |
Total number of polymer chains | 2 |
Total formula weight | 96234.70 |
Authors | Rossi, F.,Casazza, V.,Garavaglia, S.,Sathyasaikumar, K.V.,Schwarcz, R.,Kojima, S.I.,Okuwaki, K.,Ono, S.I.,Kajii, Y.,Rizzi, M. (deposition date: 2010-06-08, release date: 2010-07-28, Last modification date: 2023-12-20) |
Primary citation | Rossi, F.,Casazza, V.,Garavaglia, S.,Sathyasaikumar, K.V.,Schwarcz, R.,Kojima, S.I.,Okuwaki, K.,Ono, S.I.,Kajii, Y.,Rizzi, M. Crystal Structure-Based Selective Targeting of the Pyridoxal 5'-Phsosphate Dependent Enzyme Kynurenine Aminotransferase II for Cognitive Enhancement J.Med.Chem., 53:5684-, 2010 Cited by PubMed: 20684605DOI: 10.1021/JM100464K PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.1 Å) |
Structure validation
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