2X6O
Tet Repressor class D in complex with 7-chlor-2-cyano-iso- tetracycline
Summary for 2X6O
Entry DOI | 10.2210/pdb2x6o/pdb |
Related | 1A6I 1BJ0 1BJY 1BJZ 1DU7 1ORK 1QPI 2TCT 2TRT 2VKE 2VKV 2X9D 2XB5 2XGC 2XGD 2XGE 2XPS 2XPT 2XPU 2XPV 2XPW 2XRL |
Descriptor | TETRACYCLINE REPRESSOR PROTEIN CLASS D, (4S,4AS,6S,8AS)-6-[(1S)-7-CHLORO-4-HYDROXY-1-METHYL-3-OXO-1,3-DIHYDRO-2-BENZOFURAN-1-YL]-4-(DIMETHYLAMINO)-3,8A-DIHYDROXY-1,8-DIOXO-1,4,4A,5,6,7,8,8A-OCTAHYDRONAPHTHALENE-2-CARBONITRILE, CHLORIDE ION, ... (4 entities in total) |
Functional Keywords | transcription, transcription regulation, antibiotic resistance |
Biological source | ESCHERICHIA COLI |
Total number of polymer chains | 1 |
Total formula weight | 23820.10 |
Authors | Volkers, G.,Hinrichs, W. (deposition date: 2010-02-18, release date: 2011-03-02, Last modification date: 2023-12-20) |
Primary citation | Volkers, G.,Petruschka, L.,Hinrichs, W. Recognition of Drug Degradation Products by Target Proteins: Isotetracycline Binding to Tet Repressor. J.Med.Chem., 54:5108-, 2011 Cited by PubMed: 21699184DOI: 10.1021/JM200332E PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.3 Å) |
Structure validation
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