2W2W

PLCg2 Split Pleckstrin Homology (PH) Domain

Summary for 2W2W

Entry DOI	10.2210/pdb2w2w/pdb
Related	2W2T 2W2V 2W2X
Descriptor	1-PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2 (1 entity in total)
Functional Keywords	hydrolase, phospholipase c, phosphoinositides, rho gtpases, rac, sh2 domain, sh3 domain
Biological source	HOMO SAPIENS (HUMAN)
Total number of polymer chains	12
Total formula weight	170433.84
Authors	Opaleye, O.,Bunney, T.D.,Roe, S.M.,Pearl, L.H. (deposition date: 2008-11-04, release date: 2009-05-05, Last modification date: 2023-12-13)
Primary citation	Bunney, T.D.,Opaleye, O.,Roe, S.M.,Vatter, P.,Baxendale, R.W.,Walliser, C.,Everett, K.L.,Josephs, M.B.,Christow, C.,Rodrigues-Lima, F.,Gierschik, P.,Pearl, L.H.,Katan, M. Structural Insights Into Formation of an Active Signaling Complex between Rac and Phospholipase C Gamma 2. Mol.Cell, 34:223-, 2009 Cited by PubMed: 19394299 DOI: 10.1016/J.MOLCEL.2009.02.023 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.8 Å)

Structure validation