2VXT

Crystal structure of human IL-18 complexed to murine reference antibody 125-2H Fab

Summary for 2VXT

• Entry DOI: 10.2210/pdb2vxt/pdb
• Related: 1J0S 2VXU 2VXV
• Descriptor: MURINE IGG 125-2H, INTERLEUKIN-18, CHLORIDE ION, ... (6 entities in total)
• Functional Keywords: fab, il-18, secreted, cytokine, autoimmunity, glycoprotein, th1/th2 cells, immunoglobulin domain, immunoglobulin v region
• Biological source: MUS MUSCULUS (MOUSE); More
• Total number of polymer chains: 3
• Total formula weight: 65092.66

Authors

Argiriadi, M.A.,Xiang, T.,Wu, C.,Ghayur, T.,Borhani, D.W. (deposition date: 2008-07-10, release date: 2009-06-23, Last modification date: 2023-12-13)

• Primary citation: Argiriadi, M.A.,Xiang, T.,Wu, C.,Ghayur, T.,Borhani, D.W.; Unusual Water-Mediated Antigenic Recognition of the Proinflammatory Cytokine Interleukin-18.; J.Biol.Chem., 284:24478-, 2009; PubMed: 19553661; DOI: 10.1074/JBC.M109.023887

Experimental method

X-RAY DIFFRACTION (1.49 Å)