2VXT

Crystal structure of human IL-18 complexed to murine reference antibody 125-2H Fab

Functional Information from GO Data

Chain	GOid	namespace	contents
I	0005125	molecular_function	cytokine activity
I	0005615	cellular_component	extracellular space
I	0006954	biological_process	inflammatory response
I	0006955	biological_process	immune response

Functional Information from PDB Data

site_id	AC1
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CL H 1214

Chain	Residue
H	TYR59
H	ARG64

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site_id	AC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CL I 1193

Chain	Residue
I	HIS145
I	ASP146
I	ASN147
I	LYS148
I	HOH2081

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site_id	AC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE MG I 1194

Chain	Residue
I	HOH2070
I	HOH2042
I	HOH2069

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Functional Information from PROSITE/UniProt

site_id	PS00290
Number of Residues	7
Details	IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YTCEATH

Chain	Residue	Details
L	TYR192-HIS198

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	SITE: Cleavage; by CASP3 => ECO:0000269|PubMed:37993714, ECO:0000269|PubMed:9334240

Chain	Residue	Details
I	ASP71

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