2VXT
Crystal structure of human IL-18 complexed to murine reference antibody 125-2H Fab
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | H | MURINE IGG 125-2H | polymer | 216 | 23260.0 | 1 | MUS MUSCULUS (MOUSE) | ||
| 2 | I | INTERLEUKIN-18 | polymer | 157 | 18111.5 | 1 | UniProt (Q14116) Pfam (PF00340) In PDB | HOMO SAPIENS (HUMAN) | IL-18, INTERFERON-GAMMA-INDUCING FACTOR, IFN-GAMMA-INDUCING FACTOR, INTERLEUKIN-1 GAMMA, IL-1 GAMMA, IBOCTADEKIN |
| 3 | L | MURINE IGG 125-2H | polymer | 214 | 23626.0 | 1 | MUS MUSCULUS (MOUSE) | ||
| 4 | H, I | CHLORIDE ION | non-polymer | 35.5 | 2 | Chemie (CL) | |||
| 5 | I | MAGNESIUM ION | non-polymer | 24.3 | 1 | Chemie (MG) | |||
| 6 | water | water | 18.0 | 593 | Chemie (HOH) |
Sequence modifications
I: 37 - 193 (UniProt: Q14116)
| PDB | External Database | Details |
|---|---|---|
| Ala 74 | Cys 74 | engineered mutation |
| Ala 104 | Cys 104 | engineered mutation |
| Ala 112 | Cys 112 | engineered mutation |
| Ala 163 | Cys 163 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 64997.4 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 95.2 | |
| All* | Total formula weight | 65092.7 |
