2RL8

Crystal Structure cation-dependent mannose 6-phosphate receptor at pH 6.5 bound to M6P

Summary for 2RL8

Entry DOI	10.2210/pdb2rl8/pdb
Related	2RL6 2RL7 2RL9 2RLB
Descriptor	Cation-dependent mannose-6-phosphate receptor, 2-acetamido-2-deoxy-beta-D-glucopyranose, MANGANESE (II) ION, ... (5 entities in total)
Functional Keywords	p-type lectin, receptor, mannose 6-phosphate, lectin, glycoprotein, lysosome, membrane, transmembrane, transport, protein transport, sugar binding protein
Biological source	Bos taurus (cattle)
Cellular location	Lysosome membrane ; Single-pass type I membrane protein : P11456
Total number of polymer chains	2
Total formula weight	35959.72
Authors	Olson, L.J.,Hindsgaul, O.,Kim, J.-J.P.,Dahms, N.M. (deposition date: 2007-10-18, release date: 2008-02-12, Last modification date: 2021-10-20)
Primary citation	Olson, L.J.,Hindsgaul, O.,Dahms, N.M.,Kim, J.J. Structural Insights into the Mechanism of pH-dependent Ligand Binding and Release by the Cation-dependent Mannose 6-Phosphate Receptor. J.Biol.Chem., 283:10124-10134, 2008 Cited by PubMed: 18272523 DOI: 10.1074/jbc.M708994200 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.45 Å)

Structure validation