2RL8
Crystal Structure cation-dependent mannose 6-phosphate receptor at pH 6.5 bound to M6P
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Cation-dependent mannose-6-phosphate receptor | polymer | 154 | 17443.6 | 2 | UniProt (P11456) Pfam (PF02157) | Bos taurus (cattle) | CD Man-6-P receptor, CD-MPR, 46 kDa mannose 6-phosphate receptor, MPR 46 |
| 2 | C, F (A, B) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 2 | Chemie (NAG) | |||
| 3 | D, G (A, B) | MANGANESE (II) ION | non-polymer | 54.9 | 2 | Chemie (MN) | |||
| 4 | E, H (A, B) | 6-O-phosphono-beta-D-mannopyranose | non-polymer | 260.1 | 2 | Chemie (M6D) | |||
| 5 | I, J (A, B) | water | water | 18.0 | 346 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 154 (UniProt: P11456)
| PDB | External Database | Details |
|---|---|---|
| Gln 31 | Asn 59 | engineered mutation |
| Gln 57 | Asn 85 | engineered mutation |
| Gln 68 | Asn 96 | engineered mutation |
| Gln 87 | Asn 115 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 34887.2 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 1072.6 | |
| All* | Total formula weight | 35959.7 |
