2R2L
Structure of Farnesyl Protein Transferase bound to PB-93
Summary for 2R2L
Entry DOI | 10.2210/pdb2r2l/pdb |
Descriptor | Farnesyltransferase subunit alpha, Farnesyltransferase subunit beta, ZINC ION, ... (6 entities in total) |
Functional Keywords | malaria, fpt, transferase, metal-binding, phosphorylation, prenyltransferase, zinc |
Biological source | Rattus norvegicus (Norway rat) More |
Total number of polymer chains | 2 |
Total formula weight | 83807.27 |
Authors | Strickland, C.O.,Voorhis, W. (deposition date: 2007-08-27, release date: 2008-03-11, Last modification date: 2024-02-21) |
Primary citation | Van Voorhis, W.C.,Rivas, K.L.,Bendale, P.,Nallan, L.,Horney, C.,Barrett, L.K.,Bauer, K.D.,Smart, B.P.,Ankala, S.,Hucke, O.,Verlinde, C.L.,Chakrabarti, D.,Strickland, C.,Yokoyama, K.,Buckner, F.S.,Hamilton, A.D.,Williams, D.K.,Lombardo, L.J.,Floyd, D.,Gelb, M.H. Efficacy, pharmacokinetics, and metabolism of tetrahydroquinoline inhibitors of Plasmodium falciparum protein farnesyltransferase. Antimicrob.Agents Chemother., 51:3659-3671, 2007 Cited by PubMed: 17606674DOI: 10.1128/AAC.00246-07 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.23 Å) |
Structure validation
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