2Q5P

Crystal Structure of PPARgamma bound to partial agonist MRL24

Summary for 2Q5P

Entry DOI	10.2210/pdb2q5p/pdb
Related	2Q59 2Q5S 2Q61 2Q6R 2Q6S
Descriptor	Peroxisome Proliferator-Activated Receptor gamma, (2S)-2-(3-{[1-(4-METHOXYBENZOYL)-2-METHYL-5-(TRIFLUOROMETHOXY)-1H-INDOL-3-YL]METHYL}PHENOXY)PROPANOIC ACID (3 entities in total)
Functional Keywords	protein-ligand complex, ligand binding protein
Biological source	Homo sapiens (human)
Cellular location	Nucleus: P37231
Total number of polymer chains	2
Total formula weight	63645.60
Authors	Bruning, J.B.,Nettles, K.W. (deposition date: 2007-06-01, release date: 2007-10-23, Last modification date: 2023-08-30)
Primary citation	Bruning, J.B.,Chalmers, M.J.,Prasad, S.,Busby, S.A.,Kamenecka, T.M.,He, Y.,Nettles, K.W.,Griffin, P.R. Partial Agonists Activate PPARgamma Using a Helix 12 Independent Mechanism Structure, 15:1258-1271, 2007 Cited by PubMed: 17937915 DOI: 10.1016/j.str.2007.07.014 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.3 Å)

Structure validation