2PEZ
Crystal structrue of deletion mutant of APS-kinase domain of human PAPS-synthetase 1 in complex with cyclic PAPS and dADP
Summary for 2PEZ
Entry DOI | 10.2210/pdb2pez/pdb |
Related | 2PEY |
Descriptor | Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1 (PAPS synthetase 1) (PAPSS 1) (Sulfurylase kinase 1) (SK1) (SK 1), (2S,3AR,4R,6R,6AR)-4-(6-AMINO-9H-PURIN-9-YL)-6-({[(R)-HYDROXY(SULFOOXY)PHOSPHORYL]OXY}METHYL)TETRAHYDROFURO[3,4-D][1,3,2]DIOXAPHOSPHOL-2-OL 2-OXIDE, 2'-DEOXYADENOSINE-5'-DIPHOSPHATE, ... (4 entities in total) |
Functional Keywords | nmp-kinase fold, protein in complex with nucleic acid, transferase |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 2 |
Total formula weight | 41060.59 |
Authors | Sekulic, N.,Lavie, A. (deposition date: 2007-04-03, release date: 2007-05-29, Last modification date: 2023-08-30) |
Primary citation | Sekulic, N.,Konrad, M.,Lavie, A. Structural mechanism for substrate inhibition of the adenosine 5'-phosphosulfate kinase domain of human 3'-phosphoadenosine 5'-phosphosulfate synthetase 1 and its ramifications for enzyme regulation. J.Biol.Chem., 282:22112-22121, 2007 Cited by PubMed: 17540769DOI: 10.1074/jbc.M701713200 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.4 Å) |
Structure validation
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