2PEZ
Crystal structrue of deletion mutant of APS-kinase domain of human PAPS-synthetase 1 in complex with cyclic PAPS and dADP
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1 (PAPS synthetase 1) (PAPSS 1) (Sulfurylase kinase 1) (SK1) (SK 1) | polymer | 179 | 19874.5 | 2 | UniProt (O43252) Pfam (PF01583) | Homo sapiens (human) | |
| 2 | C (A) | (2S,3AR,4R,6R,6AR)-4-(6-AMINO-9H-PURIN-9-YL)-6-({[(R)-HYDROXY(SULFOOXY)PHOSPHORYL]OXY}METHYL)TETRAHYDROFURO[3,4-D][1,3,2]DIOXAPHOSPHOL-2-OL 2-OXIDE | non-polymer | 489.2 | 1 | Chemie (GGZ) PubChem (12876354) | |||
| 3 | D, E (A, B) | 2'-DEOXYADENOSINE-5'-DIPHOSPHATE | non-polymer | 411.2 | 2 | Chemie (DAT) PubChem (620) PubChem (177678916) PubChem (53477733) PubChem (56988235) PubChem (188966) PubChem (92449116) PubChem (92449115) PubChem (92132338) PubChem (92436381) PubChem (92449117) PubChem (92449118) | |||
| 4 | F, G (A, B) | water | water | 18.0 | 331 | Chemie (HOH) |
Sequence modifications
A, B: 51 - 226 (UniProt: O43252)
| PDB | External Database | Details |
|---|---|---|
| Gly -2 | - | cloning artifact |
| His -1 | - | cloning artifact |
| Met 0 | - | cloning artifact |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 39748.9 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 1311.7 | |
| All* | Total formula weight | 41060.6 |
