2PEZ

Crystal structrue of deletion mutant of APS-kinase domain of human PAPS-synthetase 1 in complex with cyclic PAPS and dADP

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000103	biological_process	sulfate assimilation
A	0004020	molecular_function	adenylylsulfate kinase activity
A	0005524	molecular_function	ATP binding
B	0000103	biological_process	sulfate assimilation
B	0004020	molecular_function	adenylylsulfate kinase activity
B	0005524	molecular_function	ATP binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	18
Details	BINDING SITE FOR RESIDUE GGZ A 401

Chain	Residue
A	SER61
A	LYS171
A	LEU173
A	GLY184
A	PHE185
A	THR186
A	HOH538
A	HOH595
A	HOH626
A	HOH656
A	ARG92
A	PHE101
A	ARG106
A	ASN109
A	PHE131
A	ILE132
A	SER133
A	PRO134

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site_id	AC2
Number of Residues	22
Details	BINDING SITE FOR RESIDUE DAT A 500

Chain	Residue
A	LEU60
A	SER61
A	GLY62
A	ALA63
A	GLY64
A	LYS65
A	THR66
A	THR67
A	ARG168
A	VAL170
A	THR204
A	CYS207
A	ASP208
A	VAL209
A	CYS212
A	HOH522
A	HOH533
A	HOH590
A	HOH595
A	HOH609
B	HIS163
B	GLN167

---

site_id	AC3
Number of Residues	22
Details	BINDING SITE FOR RESIDUE DAT B 600

Chain	Residue
A	HIS163
A	GLN167
B	LEU60
B	GLY62
B	ALA63
B	GLY64
B	LYS65
B	THR66
B	THR67
B	ARG168
B	VAL170
B	THR204
B	CYS207
B	ASP208
B	VAL209
B	CYS212
B	HOH616
B	HOH653
B	HOH658
B	HOH701
B	HOH704
B	HOH713

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	10
Details	Binding site: {"evidences":[{"source":"PubMed","id":"15755455","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17276460","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17540769","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1X6V","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1XJQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1XNJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2OFX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2PEY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2PEZ","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	10
Details	Binding site: {"evidences":[{"source":"PubMed","id":"17276460","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"2OFX","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	9
Details	Binding site: {"evidences":[{"source":"PubMed","id":"17276460","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"17540769","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"2OFX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2PEZ","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI4
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"15755455","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17276460","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17540769","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1X6V","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1XJQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1XNJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2OFW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2OFX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2PEY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2PEZ","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI5
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"17276460","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2OFX","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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