2PBW

Crystal Structure of the Ligand-Binding Core of iGluR5 in Complex with the Partial agonist Domoic Acid at 2.5 A Resolution

Summary for 2PBW

Entry DOI	10.2210/pdb2pbw/pdb
Related	1VSO 1YAE 1YCJ
Descriptor	Glutamate receptor, ionotropic kainate 1, (2S,3S,4S)-2-CARBOXY-4-[(1Z,3E,5R)-5-CARBOXY-1-METHYL-1,3-HEXADIENYL]-3-PYRROLIDINEACETIC ACID (3 entities in total)
Functional Keywords	agonist complex, membrane protein
Biological source	Rattus norvegicus (Norway rat) More
Cellular location	Cell membrane; Multi-pass membrane protein: P22756
Total number of polymer chains	2
Total formula weight	58839.57
Authors	Hald, H.,Naur, P.,Gajhede, M.,Kastrup, J.S. (deposition date: 2007-03-29, release date: 2007-07-03, Last modification date: 2023-08-30)
Primary citation	Hald, H.,Naur, P.,Pickering, D.S.,Sprogoe, D.,Madsen, U.,Timmermann, D.B.,Ahring, P.K.,Liljefors, T.,Schousboe, A.,Egebjerg, J.,Gajhede, M.,Kastrup, J.S. Partial agonism and antagonism of the ionotropic glutamate receptor iGLuR5: structures of the ligand-binding core in complex with domoic acid and 2-amino-3-[5-tert-butyl-3-(phosphonomethoxy)-4-isoxazolyl]propionic acid. J.Biol.Chem., 282:25726-25736, 2007 Cited by PubMed: 17581823 DOI: 10.1074/jbc.M700137200 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.5 Å)

Structure validation