2PBW

Crystal Structure of the Ligand-Binding Core of iGluR5 in Complex with the Partial agonist Domoic Acid at 2.5 A Resolution

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0015276	molecular_function	ligand-gated monoatomic ion channel activity
A	0016020	cellular_component	membrane
B	0015276	molecular_function	ligand-gated monoatomic ion channel activity
B	0016020	cellular_component	membrane

Functional Information from PDB Data

site_id	AC1
Number of Residues	14
Details	BINDING SITE FOR RESIDUE DOQ A 401

Chain	Residue
A	GLU13
A	SER141
A	THR142
A	GLU190
A	HOH426
A	HOH466
A	LYS60
A	TYR61
A	PRO88
A	THR90
A	ARG95
A	ARG138
A	ASP139
A	GLY140

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site_id	AC2
Number of Residues	15
Details	BINDING SITE FOR RESIDUE DOQ B 402

Chain	Residue
B	GLU13
B	LYS60
B	TYR61
B	PRO88
B	THR90
B	ARG95
B	ARG138
B	GLY140
B	SER141
B	THR142
B	GLU190
B	HOH406
B	HOH430
B	HOH454
B	HOH556

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	8
Details	BINDING: BINDING => ECO:0000269|PubMed:15710405, ECO:0007744|PDB:1YCJ

Chain	Residue	Details
A	PRO88
A	THR90
A	SER141
A	THR142
B	PRO88
B	THR90
B	SER141
B	THR142

---

site_id	SWS_FT_FI2
Number of Residues	4
Details	BINDING: BINDING => ECO:0000269|PubMed:15710405, ECO:0000269|PubMed:15721240, ECO:0007744|PDB:1YCJ

Chain	Residue	Details
A	ARG95
A	GLU190
B	ARG95
B	GLU190

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	MOD_RES: Phosphoserine; by PKC => ECO:0000255

Chain	Residue	Details
A	SER162
B	SER162

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site_id	SWS_FT_FI4
Number of Residues	2
Details	MOD_RES: Phosphothreonine; by PKC => ECO:0000255

Chain	Residue	Details
A	THR198
B	THR198

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site_id	SWS_FT_FI5
Number of Residues	4
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255

Chain	Residue	Details
A	ASN3
A	ASN203
B	ASN3
B	ASN203

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